Analysis of Factors Affecting the Change in Axial Length of Premature Infant's Eye

PURPOSE: To analyze the effect of presence with or absent of retinopathy of prematurity (ROP) and its stage, birth weight, conceptual age and associated diseases on the axial length of premature infants' eye. METHODS: A total of 102 eyes of 51 premature infants less than 36 weeks of conceptual age were evaluated in this study. Fundus examination for ROP and axial length measurement were conducted at 40, 52 and 64 weeks of postconceptual age. The medical records were reviewed retrospectively. Independent t-test analysis, simple regression analysis, and one-way ANOVA were performed to assess the influence of each factor on axial length. RESULTS: The mean axial length at 40, 52 and 64 weeks were 17.35, 18.80 and 19.78 mm, respectively. The mean axial length with and without ROP at 40 weeks were 17.10 mm and 17.54 mm, respectively, which were statistically significant (p=0.000). There was a significant decrease in axial length at 40 weeks in the higher ROP stage (p<0.05). Axial length and birth weight showed positive correlation with statistical significance at 40 weeks, while these parameters showed no significant correlation at 64 weeks. Axial length and conceptual age showed a positive correlation with statistical significance at 40 weeks (p=0.000), yet a negative correlation at 64 weeks with no statistical significance (p=0.306). A significant difference was not observed between sex and the associated diseases. CONCLUSIONS: The factors that affect the axial length of an infants'eye at 40 weeks were ROP and its stage, birth weight, and conceptual age. Additionally, there was no significant relationship between sex and the associated diseases.

The Size of Extraocular Muscles Estimated by Computed Tomography in Patients Undergoing Orbital Wall Fracture Repair

PURPOSE: To determine the cross sections of extraocular muscles in patients with orbital fracture and to demonstrate a relationship among the cross sections, the size of orbital fracture, the soft tissue, and fat herniation and limitation of ocular movement. METHODS: The study included 87 patients (87 eyes) with orbital fracture. The cross section was defined as multiplication of the long axis and short axis. The ratio of the cross section in normal and injured eyes was calculated at preoperative and postoperative periods. RESULTS: The cross sections of all rectus muscles, except for the superior, increased in injured eyes and subsequently decreased postoperatively. After surgery, the cross sections of lateral and medial rectus muscles recovered to near normal but the inferior remained enlarged. The increased ratio of the short and long axis was significant but not the difference of the cross sections related to the short and long axis ratio. There was a preoperative difference between injured/normal cross section ratio in relation to the size of inferior fracture. There was postoperative normalization for the cross sections of inferior rectus muscles with the restrictive limitation due to inferior fracture. CONCLUSIONS: The cross sections increased mostly after orbital fracture and subsequently decreased postoperatively. There was a change in the cross section ratio with the size of inferior fracture at preoperative period but there was no change in the cross sections related to the restrictive or paralytic limitation, except for eyes with the restriction secondary to inferior fracture. These were significantly normalized postoperatively in cross section.

Exophthalmometric Values With Hertel Exophthalmometers in Children

PURPOSE: To investigate the normal exophthalmometric values in children and facilitate the exophthalmic evaluation in pediatric patients with orbital disease. METHODS: We measured 516 eyes in 258 children aged 3 to 9 years without any orbital disease such as thyroid ophthamopathy, orbital pseudotumor and orbital wall fracture. We considered the association of age, sex, binocular variance, inter rim distance and axial length with the exophthalmometric values. Axial length was measured in only 120 eyes of60 patients who underwent operation for strabismus. RESULTS: The mean exophthalmometric values in the patients was 12.43+/-1.55 mm. The exophthalmos had a significant positive correlation with the age, axial length and inter rim distance. There were significant differences in exophthalmometric values by sex in children aged from 8 to 9 years but no significant difference by binocular variance. There were significant differences in the inter-rim distance related to sex. CONCLUSIONS: The exophthalmometric values in children had significant correlation with age, sex, axial length, and inter-rim distance. There was a significant increase of inter-rim distance in males compared to females. Knowing the mean exophthalmometric values in children would be useful with the exophthalmometric reference in pediatric patients with orbital disease.

The Characteristics of Infants with Congenital Nasolacrimal Duct Obstruction Iimproved with Lacrimal Sac Digital Massage

PURPOSE: The treatments for congenital nasolacrimal duct obstruction range from minimally invasive to more invasive methods. Initially, clinicians select lacrimal sac massage with topical antibiotics application or early lacrimal sac probing. We studied if the characteristics of infants improved after lacrimal sac massage with topical antibiotic application. METHODS: Two hundred thirty-four eyes of 204 patients diagnosed with congenital nasolacrimal duct obstruction from March 2001 to January 2007 were included. Excluded were infants who had obvious epiblepharon or eyelid abnormalities, tumors of the lacrimal system, or a history of trauma. Neonates less than 1 month were also excluded to rule out neonatal conjunctivitis. At the first visit, we recorded birth profile information such as gestational age, birth weight and height, onset time of symptoms, and post-conceptional age. We compared the results between the successful treatment group and failure group after lacrimal sac massage and topical antibiotic application. RESULTS: One hundred twenty-three eyes showed improvement after conservative treatment (52.6%), and the infants included in the success group visited earlier and had lower PCA (P<0.05). No other factors evaluated in this study contributed toward the improvement in symptoms observed. CONCLUSIONS: When considering treatment for congenital nasolacrimal duct obstruction, an evaluation of factors related to birth should be performed. According to the results, infants with the characteristics of favorable outcome should be treated conservatively, while those patients who do not have the characteristics for favorable outcome should be treated by early probing to achieve an effective and satisfactory outcome.

Progression of Myopia in the Patients with Astigmatism over 3.0 Diopters

PURPOSE: To compare myopia progression in patients with astigmatism over 3.0 dipoters and in patients with astigmatism with less than 1.0 diopter. METHODS: Between March 2001 and March 2006, regular refraction was performed in patients without amblyopia or strabismus. Patients with astigmatism over 3.0 diopter were classified into subject group, and patients with astigmatism less than 1.0 diopter were classified into control group. We performed cycloplegic refraction at the first visit, and manifest refraction at follow-up examination. Minimal follow-up period was 12 months. Data analysis was performed with T-test and ANOVA. RESULTS: There was no difference in myopia progression in patients with astigmatism over 3.0 dipoters and in patients with astigmatism with less than 1.0 diopter. Age, sex, type of astigmatism, spherical equivalent, age to start wearing glasses, and time to watch television and computer didn't show significant influence on myopic progression in subject group and control group. Patients with astigmatism over 3.0 diopters in one eye and astigmatism less than 3.0 diopters in the other eye were evaluated and there was no difference in myopia progression between both eyes. Eyes with non-progressive astigmatism over 3.0 diopters showed similar myopia progression with eyes with progressive astigmatism over 3.0 diopters. CONCLUSIONS: There was no difference in myopia progression between patients with astigmatism over 3.0 dipoters and patients with astigmatism with less than 1.0 diopter.

Therapeutic Effect of Botulinum Toxin Injection in Eyelid Myokymia Patients

PURPOSE: To evaluate clinical manifestations and effects of botulinum toxin in eyelid myokymia patients. METHODS: Between March 2001 and March 2005, botulinum toxin injection therapy was performed in 12 eyelid myokymia patients. We evaluated duration of disease, systemic disease, drug history, and range, grade, frequency of myokymia at the first visit. Botulinum injections were performed in patients with normal results of blood tests and neuroimaging tests. Improvement of symptoms, duration of effectiveness, and complications were evaluated after the botulinum toxin injection therapies. Data was analyzed with the Mann-Whitney U test. RESULTS: Improvement of symptoms was noticed in 10 patients (83.3%). Among the 10 patients, 5 patients were decided as cured patients because they did not require any retreatment. Range and grade of myokymia didn't affect on effect of treatment. Pain, edema, excessive tearing, and unnatural face were noticed as complications of treatment, but all complications disappeared 2 weeks after the treatment. CONCLUSIONS: Botulinum toxin injection therapy is noninvasive and effective treatment in benign eyelid myokymia patients without causal neurologic disease.

Correspondence among the Canaliculus Irrigation Test, Dacryocystography and Jones Test in the Epiphora Patients

PURPOSE: The correspondence between the canaliculus irrigation test, dacryocystography, and Jones test in patients with epiphora was investigated. METHODS: The study included 494 eyes of 359 patients who complained of epiphora and underwent both canaliculus irrigation test and dacryocystography from May 2001 to March 2006. Sixty-eight eyes from 34 patients diagnosed with functional lacrimal duct obstruction took Jones tests. Factors such as age, sex, duration of epiphora, and site of obstruction were analyzed in terms of correspondence of the tests. RESULTS: Between the canaliculus irrigation test and dacryocystography, correspondent rate was 55%. Correspondence had no relation to patient age, sex, duration of epiphora, or site of obstruction. Between Jones test and dacryocystography, the correspondent rate was 47%. Factors affecting the correspondences were not significantly found. CONCLUSIONS: A canaliculus irrigation test can give useful information with high correspondence rate of dacryocystography in the case of 'not pass' or 'pass without regurgitation'. Therefore dacryocystography should be utilized in "pass with regurgitation" cases by canaliculus irrigation test.

A Case of Infantile Nystagmus in a Child with Schizencephaly

PURPOSE: Nystagmus is a rare involuntary eye movement which has no known, specific, underlying diseases. Schizencephaly is also a rare disease. A child with generalized developmental delay came to the pediatric clinic. He showed schizencephaly on MRI, and was referred to department of rehabilitation. During rehabilitative evaluation, the patient was referred to the department of ophthalmology due to esotropia. We found that the patient had little esotropia, but did have nystagmus. Therefore, we report a case of congenital nystagmus associated with schizencephaly. METHODS: A one-year-old boy showing schizencephaly on MRI and esotropia underwent examination. RESULTS: The patient did not have a remarkable past or familial history, and didn't show any other anomaly. There were no abnormal findings on slit lamp examination, and according to strabismus studies, he showed very little esotropia. He did show nystagmus. We couldn't find any significant refractive error or ocular dysfunction on cycloplegic refraction and fundus examination, respectively. Visual evoked potential showed normal findings. On MRI, ordered by the pediatrician, open-lip type schizencephaly on the right frontal lobe and absence of septum pellucidum were seen. There was no endocrinologic abnormality. CONCLUSIONS: We report the case of a child with congenital nystagmus accompanied by schizencephaly, and present a literature review.

The Result of Botulinum Toxin A Injection in the Upper Eyelid Retraction of Thyroid-Associated Ophthalmopathy Patients

PURPOSE: This study is to determine the effects of botulinum toxin injection on patients who suffer from upper eyelid retraction caused by thyroid ophthalmopathy. METHODS: We injected 10-15 units botulinum toxin (Botox(R), Allergan, USA) on the upper tarsus of 12 eyes of 12 thyroid ophthalmopathy patients and compared duration of disease, clinical activity scores (CAS), intraocular pressures (mmHg), exophthalmometry (mm), upper eyelid retraction (mm), marginal reflex distance1 (MRD1, mm), levator function test (mm), lid lag (mm), limitation of ocular movement (mm), lid tension test results, phenylephrine test results, and orbital computed tomography results before and after the injection. RESULTS: The patient group with smaller-sized cross section of superior rectus/levator complex before the injection showed a greater decrease of upper eyelid retraction after the injection (p=0.04). Other clinical parameters showed no significant relations on the effect of the toxin injection. CONCLUSIONS: Botulinum toxin injection can have variable effects on the upper eyelid retraction of thyroid ophthalmopathy patients. The patients who had smaller volume of superior rectus/levator complex measured in orbital cross sections on CT, could expect good results after botulinum toxin injection.

Spontaneous Regression of Exodeviation in Intermittent Exotropia

PURPOSE: To compare the characteristics of the intermittent exotropia patients with spontaneous regression to the surgically corrected group. METHODS: Twenty-five patients who had exodeviation of around 25 prism diopters (PD). Visual acuity and best corrected visual acuity were measured. The latter was obtained by using cycloplegic refraction. Far and near deviation angles were measured through alternating prism cover test. Stereo acuity was measured using a Titmus stereo acuity test chart and occlusion was performed for those who had more than 2 lines of difference between the best corrected visual acuity of the left and right eyes on the Snellen E chart. We divided the patients into two groups. The first group is the spontaneous regression group (SRG), who showed declining deviation angles and maintained less than 10 PD for more than 3 months. The second group is the surgically corrected group (SCG), showed the same or increasing deviation angle and underwent operation. RESULTS: There was no difference in the age or observation period between the two groups. The prevalence period was significantly higher in the SRG than in the SCG. The deviation angle from a distance at the first visit was not different for the SCG from that of the SRG. However, the deviation angle at near was significantly larger for the SCG than that of the SRG and increased at the last examination. Stereo acuity of the SRG was better than that of the SCG at the first visit. CONCLUSIONS: Deviation angle could be reduced in the mild intermittent exotropia patients with relatively small deviation angle at near or with good stereo acuity.

Surgical Result of Intermittent Exotropia According to Angle of Deviation at Lateral Gaze

PURPOSE: This study investigated the surgical result of intermittent exotropia according to the difference between primary gaze and lateral gaze, where the extent of surgical treatment was decided by the angle of deviation in primary gaze. METHODS: The subjects of this study were 128 patients who had intermittent exotropia and were operated on by the same surgeon. Deviation angle of strabismus was checked at near and distance and primary and 30-degree lateral directions of gaze. The Worth 4 dot test and Titmus test were performed. Refixation time and axial length were measured. Either the cycloplegic refraction test or manifest refraction test was done depending on the patient's age. The extent of surgery was decided by the criteria recommended by Parks. Patients were classified into 2 groups. Group 1 included patients with 5-PD or smaller differences in the angle of deviation in the primary and lateral gaze. Patients who had differences greater than 5-PD in the angle of deviation according to the direction of gaze were classified as group 2. Clinical data were verified by Pearson Chi-square test. RESULTS: Age, sex, angle of deviation at near and distance, oblique muscle function, spherical equivalent, astigmatism, axial length, stereopsis, and refixation time did not affect the difference in the angle of deviation according to the direction of gaze. The non-fusion group showed a large difference in the angle of deviation according to the direction of gaze. The extent of surgery was determined by the deviation angle in primary gaze. Both group showed similar surgical results. CONCLUSIONS: To determine the degree of surgery needed, it is reasonable to measure the deviation angle in primary gaze for patients with intermittent exotropia.

Dissociated Vertical Deviation with Microtia showing Familial Tendency

PURPOSE: We report two brothers having dissociated vertical deviation with microtia and familial history of the condition. METHODS: The subjects of this report are a 7-year-old patient with bilateral dissociated vertical deviation, exotropia, bilateral inferior oblique muscle overaction, and microtia, and his brother, a 6-year-old with bilateral dissociated vertical deviation, right dissociated horizontal deviation and microtia. RESULTS: The first patient underwent asymmetric bilateral lateral rectus muscle recession and bilateral inferior oblique muscle myotomy, while the second patient had asymmetric bilateral lateral rectus muscle recession. In the first patient, the exotropia was corrected, but the bilateral dissociated vertical deviation and left dissociated horizontal deviation remained. The right dissociated horizontal deviation improved in the second patient. Their father, two aunts and paternal grandmother also had strabismus and microtia. CONCLUSIONS: Physicians must investigate familial history in examining the strabismus patient with microtia. Additionally, genetic investigation is in need in more subjects of this study.

Anatomical Study of Medial Orbit in Human Cadavers

PURPOSE: This study investigated the anatomy of the anterior ethmoidal foramen, posterior ethmoidal foramen, optic foramen, and nasolacrimal duct located in the medial orbit. METHODS: The subjects of this investigation were 20 eyes of 10 cadavers, three were male and seven were female. After exenteration, anatomic evaluation of medial orbit and nasolacrimal duct were performed. The results were verified by Mann-Whitney U test. RESULTS: The distance from the posterior lacrimal crest is 16.10+/-1.07 mm to the anterior ethmoidal foramen, 30.35+/-4.08 mm to the posterior ethmoidal foramen and 37.40+/-2.03 mm to the optic foramen. The distance is 13.95+/-1.16 mm between the anterior and posterior ethmoidal foramen, 6.45+/-1.86 mm between the posterior ethmoidal foramen and optic foramen. The distance from the anterior ethmoidal foramen to its vertical contact point from the anterior ethmoidal foramen to the base line between the posterior lacrimal crest and optic foramen is 14.68+/-2.56 mm, from This vertical contact point to the posterior lacrimal crest is 4.00+/-1.35 mm and the angle between line from the anterior ethmoidal foramen to the posterior lacrimal crest and the line from the optic foramen to the posterior lacrimal crest is 16.15+/-7.03. The distance from the posterior ethmoidal foramen to its vertical contact point from the posterior ethmoidal foramen to the base line between the posterior lacrimal crest and optic foramen is 30.88+/-2.27 mm, from this vertical contact point to the posterior lacrimal crest is 2.30+/-0.71 mm and the angle between the line from the posterior ethmoidal foramen to the posterior lacrimal crest and the line from the optic foramen to the posterior lacrimal crest is 4.43+/-1.47. The total length is 33.55+/-5.34mm, the angle are 44.98+/-6.61 degrees between the coronal plane and 36.60+/-2.19 degrees between the sagittal palne in nasolacrimal duct. CONCLUSIONS: Our study evaluate normal anatomy of the medial orbit, suggest surgical index in Korean.

Ultrasonographic Measurement of Upper Eyelid Thickness in Korean Children with Epicanthus

PURPOSE: Upper eyelid thickness was measured to determine whether there is a difference in the thickness of the upper eyelids in children with and without epicanthus. METHODS: Children were enrolled into the epicanthus group or non-epicanthus (control) group. The children with epicanthus were classified into four subgroups according to the Duke-Elder's classification. The thickness of the upper eyelid was measured at five points with A-scan ultrasonography. RESULTS: There was no significant difference in upper eyelid thickness between the epicanthus group and control group (P>0.05) or between the subgroups of the epicanthus group (P>0.05). CONCLUSIONS: This result suggests that the etiology of epicanthus may not be hypertrophy of soft tissue.

Surgical Result of Endoscopic Dacryocystorhinostomy according to Opening Size of Nasal Mucosa

PURPOSE: This study investigated the surgical results and nasal findings of an endoscopic dacryocystorhinostomy according to differences in nasal mucosal and lacrimal bone opening size. METHODS: This investigation included 40 eyes of 35 patients who had undergone endoscopic dacryocystorhinostomy by nasolacrimal duct obstruction between February 2003 and December 2004. Comparisons of nasal mucosal opening with lacrimal bone opening were performed using of digital images recorded during the operations. Opening size was defined as the definite to average length of the long and short axes of each opening. Success rates were evaluated by postoperative subjective symptoms and syringing findings. Postoperative nasal cavity findings were obtained by endonasal evaluation. The results were verified by the Pearson chi-square test. RESULTS: The success rate was higher in the group with a nasal mucosal opening size at least twice as wide as their lacrimal bone opening size (84.62%) compared to the group with a nasal mucosal opening sizes less than twice as wide as their lacrimal bone opening size (78.57%), but the difference was not significant (p=0.78). Granulation tissues were observed at a significantly lower rate in the group with nasal mucosal opening sizes at least twice as wide as their lacrimal bone opening size. CONCLUSIONS: Large resection of nasal mucosa in endoscopic dacryocystorhinostomy can improve the result by decreasing the granulation formation.

A Case of Conjunctival Benign Lymphoid Hyperplasia associated with Ptosis of the Eyelid in a Child

PURPOSE: Benign lymphoid hyperplasia of the conjunctiva occurs infrequently in children. We report a case of benign lymphoid hyperplasia, accompanied by ptosis and conjunctival injection. METHODS: A nine-year-old girl showing ptosis and conjunctival injection underwent examination. RESULTS: There was ptosis of the right eye. Ophthalmologic findings included nodules which seemed like salmon's patch in the conjunctiva. The function of the levator muscle and the Neostigmine test were normal. There was no specific finding in fundus and orbital CT. Biopsy of the nodules was done under local anesthesia, and the pathologic result was benign reactive lymphoid hyperplasia. Ofloxacin and fluorometholone eye drops were used for 6 weeks, and oral prednisolone was used for 2 weeks. The ptosis was improved 3 weeks after surgery and follow-up survey was continuing at 10 months after surgery at the time of writing. CONCLUSIONS: We report one case of a child with benign lymphoid hyperplasia of the conjunctiva who showed ptosis and conjunctival injection, and present a literature.

Ocular Motility Disturbances in Orbital Wall Fracture Patients

It is difficult to identify the exact cause of ocular motility disturbances in orbital wall fracture patients. By performing CT and ocular motility tests before and after surgery, this study analyzes the functions of the extraocular muscles and determines correlations between the results. Between February 2001 and January 2003, 45 eyes of 45 patients with orbital wall fractures, whose medical records could be traced back at least 6 months, underwent surgical repair in our hospital. All variables were analyzed using the independent t-test, paired t-test, and Chi-square test. There was no significant difference in the location and degree of fracture and the incarceration pattern of 6 patients who had moderate or severe diplopia, and of the remaining patients 6 months after surgery. However, in the case of diplopia, the sum of ocular motility limitation was 5.67 +/- 4.18, and the degree of extraocular motility disturbance was 3.67 +/- 2.42 before surgery. When there was no diplopia, the sum of ocular motility limitation was 1.13 +/- 1.38, and the degree of extraocular motility disturbance was 1.08 +/- 1.16 (p < 0.005, independent t-test). Ocular movement was successfully recovered by surgical reduction within 3 weeks from trauma. Postoperative ocular motility disturbance was more related to various ocular motility test results than CT findings. Ocular motility disturbances can remain after surgery if ocular motility limitation and extraocular motility disturbance are significant after trauma. Additional studies on the various tests to examine functions of extraocular muscles are required to identify and analyze the exact cause of ocular motility disturbance.

The Lower Eyelid Movement by Inferior Oblique Muscle Action According to the Age

PURPOSE: There have been few studies on the dynamic analysis of lower eyelid movement. The inferior oblique muscle deep in the inferior orbit is well connected with the extraocular muscle by capsulopalpebral fascia and is involved in the lower eyelid movement. The purpose of this study was to determine the graphical equation of the lower eyelid contour and to quantify the dynamic movement of the lower eyelid at primary gaze and inferior oblique action gaze in normal eyes according to age, as such findings have never been reported before. METHODS: One hundred and forty subjects who had no previous eye or eyelid disease and surgery, aged from 5 to 68 years (35.75+/-30.59 years) were enrolled and divided into 7 age groups. We analyzed digital camera images to obtain the lower eyelid curvature and traveling distance of the lowest point of the lower eyelid accompanied by the action of the inferior oblique muscle. RESULTS: Graphical analysis presented the relationship of the cubic equation resembling the lower eyelid contour. The curvature of the lower eyelid at the gaze of inferior oblique muscles action became flatter than that of the primary position in all age groups. The lowest point of the lower eyelid moved significantly to the medial position and up from the primary gaze at the gaze of the inferior oblique muscles action in all age groups. There was no difference in traveling distance of the lower eyelid at each direction between sexes and age groups. CONCLUSIONS: The lower eyelid movements associated with the inferior oblique muscle are believed to be innate. We suggest that the digital image analysis of the lower eyelid contour will be useful to analyze the lower eyelid movements.

A Case of Lacrimal Ductal Cyst with Dacryolith

PURPOSE: Lacrimal gland duct cysts constitute a rare clinical entity and may be preceded by trauma, infection, or inflammation without antecedent history. The purpose of this study is to report one case of lacrimal gland duct cyst accompanied by a dacryolith. METHODS: A 41-year-old man presented with sudden enlarging mass in the left superotemporal conjunctival fornix 3 days ago. The lesion was about 10 X 10 mm in size. There was no tenderness or erythema in adjacent area. The CT scan was done and excisional biopsy was performed under local anesthesia. RESULTS: Specimen consisted of cystic membranous tissue in 9.0 X 7.0 mm in size and mucous material and a light brown dacryolith of 1mm in diameter within cyst. Specimen included normal lacrimal tissue. Microscopic examination found cyst was covered with stratified columnal epithelium accompanied by acute and chronic inflammation and eosinophilic acellular dacryolith mixed with inflammatory exudates. There was no bacterial colony and polarizing microscope found no birefringence. CONCLUSIONS: Such case of a eosinophilic dacryolith within lacrimal gland duct cyst has never been reported at home and abroad.

Bacteriology and Antibiotic Sensitivity of Acute Bacterial Conjunctivitis in Infants

PURPOSE: We investigated the causative microorganisms and the most effective antibiotics in conjunctivitis of infants according to the delivery methods, prophylactic antibiotics, epiphora and neonatal care places. METHODS: 51 consecutive infants aged less than 1 year-old, presented to the hospital from March 2001 to March 2003 with a sign of conjunctivitis, were examined. We analyzed ocular symptoms, symptom duration, delivery method, neonatal care places, and prophylactic antibiotics of the infants. Culture from the conjunctiva and conjunctival discharge, and antibiotic sensitivity test for the detection of microorganisms were done. RESULTS: Organisms were isolated from 37 (72.5%) of 51 patients. Common causative organisms were S. aureus (25.9%), S. pneumoniae (9.3%) and H. influenzae (9.5%). The most effective antibiotic for Gram(+) as well as Gram (-) bacteria was found to be ciprofloxacin in this study. Bacterial distribution showed no difference regardless of the symptoms, symptom duration, delivery method, neonatal care places, and prophylactic antibiotics in patients less than 6month-old (P>0.05). CONCLUSIONS: The ciprofloxacin was the most effective antibiotic against the causative organisms in infantile conjunctivitis.